β-Strand mimics based on tetrahydropyridazinedione (tpd) peptide stitching.
نویسندگان
چکیده
Short peptides featuring a tetrahydropyridazinedione (tpd) backbone tether exhibit reduced conformational flexibility external to the heterocyclic constraint. Analysis by NMR, molecular modeling and X-ray crystallography suggests both covalent and non-covalent stabilization of extended peptide conformations. An efficient solid-phase protocol was developed for the synthesis of a new class of β-strand mimics based on oligomeric tpd subunits.
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ورودعنوان ژورنال:
- Chemical communications
دوره 51 90 شماره
صفحات -
تاریخ انتشار 2015